SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage
Identifieur interne : 002053 ( Main/Exploration ); précédent : 002052; suivant : 002054SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage
Auteurs : Cheng Huang [États-Unis] ; Kumari G. Lokugamage [États-Unis] ; Janet M. Rozovics [États-Unis] ; Krishna Narayanan [États-Unis] ; Bert L. Semler [États-Unis] ; Shinji Makino [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2011.
Descripteurs français
- KwdFr :
- ARN messager (génétique), ARN messager (métabolisme), ARN viral (génétique), ARN viral (métabolisme), Matrices (génétique), Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), RNA replicase (génétique), RNA replicase (métabolisme), RT-PCR, Régulation de l'expression des gènes viraux (génétique), Stabilité de l'ARN, Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- génétique : ARN messager, ARN viral, Protéines virales non structurales, RNA replicase, Régulation de l'expression des gènes viraux, Virus du SRAS.
- métabolisme : ARN messager, ARN viral, Protéines virales non structurales, RNA replicase, Virus du SRAS.
- Matrices (génétique), RT-PCR, Stabilité de l'ARN.
English descriptors
- KwdEn :
- Gene Expression Regulation, Viral (genetics), RNA Replicase (genetics), RNA Replicase (metabolism), RNA Stability, RNA, Messenger (genetics), RNA, Messenger (metabolism), RNA, Viral (genetics), RNA, Viral (metabolism), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (metabolism), Templates, Genetic, Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism).
- MESH :
- chemical , genetics : RNA Replicase, RNA, Messenger, RNA, Viral, Viral Nonstructural Proteins.
- genetics : Gene Expression Regulation, Viral, SARS Virus.
- chemical , metabolism : RNA Replicase, RNA, Messenger, RNA, Viral, SARS Virus, Viral Nonstructural Proteins.
- RNA Stability, Reverse Transcriptase Polymerase Chain Reaction, Templates, Genetic.
Abstract
SARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their translation functions and induces host mRNA degradation. Our previous study demonstrated that nsp1 induces RNA modification near the 5′-end of a reporter mRNA having a short 5′ untranslated region and RNA cleavage in the encephalomyocarditis virus internal ribosome entry site (IRES) region of a dicistronic RNA template, but not in those IRES elements from hepatitis C or cricket paralysis viruses. By using primarily cell-free,
Url:
DOI: 10.1371/journal.ppat.1002433
PubMed: 22174690
PubMed Central: 3234236
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001406
- to stream Pmc, to step Curation: 001406
- to stream Pmc, to step Checkpoint: 000B21
- to stream PubMed, to step Corpus: 001431
- to stream PubMed, to step Curation: 001431
- to stream PubMed, to step Checkpoint: 001439
- to stream Ncbi, to step Merge: 002429
- to stream Ncbi, to step Curation: 002429
- to stream Ncbi, to step Checkpoint: 002429
- to stream Main, to step Merge: 002077
- to stream Main, to step Curation: 002053
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage</title><author><name sortKey="Huang, Cheng" sort="Huang, Cheng" uniqKey="Huang C" first="Cheng" last="Huang">Cheng Huang</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G." last="Lokugamage">Kumari G. Lokugamage</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rozovics, Janet M" sort="Rozovics, Janet M" uniqKey="Rozovics J" first="Janet M." last="Rozovics">Janet M. Rozovics</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Semler, Bert L" sort="Semler, Bert L" uniqKey="Semler B" first="Bert L." last="Semler">Bert L. Semler</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22174690</idno><idno type="pmc">3234236</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234236</idno><idno type="RBID">PMC:3234236</idno><idno type="doi">10.1371/journal.ppat.1002433</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001406</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001406</idno><idno type="wicri:Area/Pmc/Curation">001406</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001406</idno><idno type="wicri:Area/Pmc/Checkpoint">000B21</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B21</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:22174690</idno><idno type="wicri:Area/PubMed/Corpus">001431</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001431</idno><idno type="wicri:Area/PubMed/Curation">001431</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001431</idno><idno type="wicri:Area/PubMed/Checkpoint">001439</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001439</idno><idno type="wicri:Area/Ncbi/Merge">002429</idno><idno type="wicri:Area/Ncbi/Curation">002429</idno><idno type="wicri:Area/Ncbi/Checkpoint">002429</idno><idno type="wicri:doubleKey">1553-7366:2011:Huang C:sars:coronavirus:nsp</idno><idno type="wicri:Area/Main/Merge">002077</idno><idno type="wicri:Area/Main/Curation">002053</idno><idno type="wicri:Area/Main/Exploration">002053</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage</title><author><name sortKey="Huang, Cheng" sort="Huang, Cheng" uniqKey="Huang C" first="Cheng" last="Huang">Cheng Huang</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G." last="Lokugamage">Kumari G. Lokugamage</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Rozovics, Janet M" sort="Rozovics, Janet M" uniqKey="Rozovics J" first="Janet M." last="Rozovics">Janet M. Rozovics</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Semler, Bert L" sort="Semler, Bert L" uniqKey="Semler B" first="Bert L." last="Semler">Bert L. Semler</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene Expression Regulation, Viral (genetics)</term><term>RNA Replicase (genetics)</term><term>RNA Replicase (metabolism)</term><term>RNA Stability</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>RNA, Viral (genetics)</term><term>RNA, Viral (metabolism)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Templates, Genetic</term><term>Viral Nonstructural Proteins (genetics)</term><term>Viral Nonstructural Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (génétique)</term><term>ARN messager (métabolisme)</term><term>ARN viral (génétique)</term><term>ARN viral (métabolisme)</term><term>Matrices (génétique)</term><term>Protéines virales non structurales (génétique)</term><term>Protéines virales non structurales (métabolisme)</term><term>RNA replicase (génétique)</term><term>RNA replicase (métabolisme)</term><term>RT-PCR</term><term>Régulation de l'expression des gènes viraux (génétique)</term><term>Stabilité de l'ARN</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA Replicase</term><term>RNA, Messenger</term><term>RNA, Viral</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation, Viral</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN messager</term><term>ARN viral</term><term>Protéines virales non structurales</term><term>RNA replicase</term><term>Régulation de l'expression des gènes viraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA Replicase</term><term>RNA, Messenger</term><term>RNA, Viral</term><term>SARS Virus</term><term>Viral Nonstructural Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>ARN viral</term><term>Protéines virales non structurales</term><term>RNA replicase</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>RNA Stability</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Templates, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Matrices (génétique)</term><term>RT-PCR</term><term>Stabilité de l'ARN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>SARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their translation functions and induces host mRNA degradation. Our previous study demonstrated that nsp1 induces RNA modification near the 5′-end of a reporter mRNA having a short 5′ untranslated region and RNA cleavage in the encephalomyocarditis virus internal ribosome entry site (IRES) region of a dicistronic RNA template, but not in those IRES elements from hepatitis C or cricket paralysis viruses. By using primarily cell-free, <italic>in vitro</italic> translation systems, the present study revealed that the nsp1 induced endonucleolytic RNA cleavage mainly near the 5′ untranslated region of capped mRNA templates. Experiments using dicistronic mRNAs carrying different IRESes showed that nsp1 induced endonucleolytic RNA cleavage within the ribosome loading region of type I and type II picornavirus IRES elements, but not that of classical swine fever virus IRES, which is characterized as a hepatitis C virus-like IRES. The nsp1-induced RNA cleavage of template mRNAs exhibited no apparent preference for a specific nucleotide sequence at the RNA cleavage sites. Remarkably, SCoV mRNAs, which have a 5′ cap structure and 3′ poly A tail like those of typical host mRNAs, were not susceptible to nsp1-mediated RNA cleavage and importantly, the presence of the 5′-end leader sequence protected the SCoV mRNAs from nsp1-induced endonucleolytic RNA cleavage. The escape of viral mRNAs from nsp1-induced RNA cleavage may be an important strategy by which the virus circumvents the action of nsp1 leading to the efficient accumulation of viral mRNAs and viral proteins during infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author><author><name sortKey="Oberste, Ms" uniqKey="Oberste M">MS Oberste</name></author><author><name sortKey="Monroe, Ss" uniqKey="Monroe S">SS Monroe</name></author><author><name sortKey="Nix, Wa" uniqKey="Nix W">WA Nix</name></author><author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R Campagnoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name></author><author><name sortKey="Jones, Sj" uniqKey="Jones S">SJ Jones</name></author><author><name sortKey="Astell, Cr" uniqKey="Astell C">CR Astell</name></author><author><name sortKey="Holt, Ra" uniqKey="Holt R">RA Holt</name></author><author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A Brooks-Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author><author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Tsoi, Hw" uniqKey="Tsoi H">HW Tsoi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M Yu</name></author><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Netland, J" uniqKey="Netland J">J Netland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhardwaj, K" uniqKey="Bhardwaj K">K Bhardwaj</name></author><author><name sortKey="Guarino, L" uniqKey="Guarino L">L Guarino</name></author><author><name sortKey="Kao, Cc" uniqKey="Kao C">CC Kao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, A" uniqKey="Cheng A">A Cheng</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Xie, Y" uniqKey="Xie Y">Y Xie</name></author><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Arnold, E" uniqKey="Arnold E">E Arnold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fan, K" uniqKey="Fan K">K Fan</name></author><author><name sortKey="Wei, P" uniqKey="Wei P">P Wei</name></author><author><name sortKey="Feng, Q" uniqKey="Feng Q">Q Feng</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imbert, I" uniqKey="Imbert I">I Imbert</name></author><author><name sortKey="Guillemot, Jc" uniqKey="Guillemot J">JC Guillemot</name></author><author><name sortKey="Bourhis, Jm" uniqKey="Bourhis J">JM Bourhis</name></author><author><name sortKey="Bussetta, C" uniqKey="Bussetta C">C Bussetta</name></author><author><name sortKey="Coutard, B" uniqKey="Coutard B">B Coutard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivanov, Ka" uniqKey="Ivanov K">KA Ivanov</name></author><author><name sortKey="Hertzig, T" uniqKey="Hertzig T">T Hertzig</name></author><author><name sortKey="Rozanov, M" uniqKey="Rozanov M">M Rozanov</name></author><author><name sortKey="Bayer, S" uniqKey="Bayer S">S Bayer</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Minskaia, E" uniqKey="Minskaia E">E Minskaia</name></author><author><name sortKey="Hertzig, T" uniqKey="Hertzig T">T Hertzig</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Campanacci, V" uniqKey="Campanacci V">V Campanacci</name></author><author><name sortKey="Cambillau, C" uniqKey="Cambillau C">C Cambillau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saikatendu, Ks" uniqKey="Saikatendu K">KS Saikatendu</name></author><author><name sortKey="Joseph, Js" uniqKey="Joseph J">JS Joseph</name></author><author><name sortKey="Subramanian, V" uniqKey="Subramanian V">V Subramanian</name></author><author><name sortKey="Clayton, T" uniqKey="Clayton T">T Clayton</name></author><author><name sortKey="Griffith, M" uniqKey="Griffith M">M Griffith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Bredenbeek, Pj" uniqKey="Bredenbeek P">PJ Bredenbeek</name></author><author><name sortKey="Dobbe, Jc" uniqKey="Dobbe J">JC Dobbe</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivanov, Ka" uniqKey="Ivanov K">KA Ivanov</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Dobbe, Jc" uniqKey="Dobbe J">JC Dobbe</name></author><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barretto, N" uniqKey="Barretto N">N Barretto</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D Jukneliene</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K Ratia</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Mesecar, Ad" uniqKey="Mesecar A">AD Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Brockway, Sm" uniqKey="Brockway S">SM Brockway</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W Kamitani</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Lokugamage, K" uniqKey="Lokugamage K">K Lokugamage</name></author><author><name sortKey="Ikegami, T" uniqKey="Ikegami T">T Ikegami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindner, Ha" uniqKey="Lindner H">HA Lindner</name></author><author><name sortKey="Fotouhi Ardakani, N" uniqKey="Fotouhi Ardakani N">N Fotouhi-Ardakani</name></author><author><name sortKey="Lytvyn, V" uniqKey="Lytvyn V">V Lytvyn</name></author><author><name sortKey="Lachance, P" uniqKey="Lachance P">P Lachance</name></author><author><name sortKey="Sulea, T" uniqKey="Sulea T">T Sulea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sulea, T" uniqKey="Sulea T">T Sulea</name></author><author><name sortKey="Lindner, Ha" uniqKey="Lindner H">HA Lindner</name></author><author><name sortKey="Purisima, Eo" uniqKey="Purisima E">EO Purisima</name></author><author><name sortKey="Menard, R" uniqKey="Menard R">R Menard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W Kamitani</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Lokugamage, K" uniqKey="Lokugamage K">K Lokugamage</name></author><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W Kamitani</name></author><author><name sortKey="Ikegami, T" uniqKey="Ikegami T">T Ikegami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wathelet, Mg" uniqKey="Wathelet M">MG Wathelet</name></author><author><name sortKey="Orr, M" uniqKey="Orr M">M Orr</name></author><author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zust, R" uniqKey="Zust R">R Zust</name></author><author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragan</name></author><author><name sortKey="Kuri, T" uniqKey="Kuri T">T Kuri</name></author><author><name sortKey="Blakqori, G" uniqKey="Blakqori G">G Blakqori</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tohya, Y" uniqKey="Tohya Y">Y Tohya</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W Kamitani</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Lokugamage, K" uniqKey="Lokugamage K">K Lokugamage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name></author><author><name sortKey="Rozovics, Jm" uniqKey="Rozovics J">JM Rozovics</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fitzgerald, Kd" uniqKey="Fitzgerald K">KD Fitzgerald</name></author><author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, Rj" uniqKey="Jackson R">RJ Jackson</name></author><author><name sortKey="Kaminski, A" uniqKey="Kaminski A">A Kaminski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kieft, Js" uniqKey="Kieft J">JS Kieft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hellen, Cu" uniqKey="Hellen C">CU Hellen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Salas, E" uniqKey="Martinez Salas E">E Martinez-Salas</name></author><author><name sortKey="Pacheco, A" uniqKey="Pacheco A">A Pacheco</name></author><author><name sortKey="Serrano, P" uniqKey="Serrano P">P Serrano</name></author><author><name sortKey="Fernandez, N" uniqKey="Fernandez N">N Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Todd, S" uniqKey="Todd S">S Todd</name></author><author><name sortKey="Towner, Js" uniqKey="Towner J">JS Towner</name></author><author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorner, Aj" uniqKey="Dorner A">AJ Dorner</name></author><author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name></author><author><name sortKey="Jackson, Rj" uniqKey="Jackson R">RJ Jackson</name></author><author><name sortKey="Hanecak, R" uniqKey="Hanecak R">R Hanecak</name></author><author><name sortKey="Duprey, E" uniqKey="Duprey E">E Duprey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belsham, Gj" uniqKey="Belsham G">GJ Belsham</name></author><author><name sortKey="Sonenberg, N" uniqKey="Sonenberg N">N Sonenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Ke" uniqKey="Murray K">KE Murray</name></author><author><name sortKey="Roberts, Aw" uniqKey="Roberts A">AW Roberts</name></author><author><name sortKey="Barton, Dj" uniqKey="Barton D">DJ Barton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunt, Sl" uniqKey="Hunt S">SL Hunt</name></author><author><name sortKey="Jackson, Rj" uniqKey="Jackson R">RJ Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Breyne, S" uniqKey="De Breyne S">S de Breyne</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Unbehaun, A" uniqKey="Unbehaun A">A Unbehaun</name></author><author><name sortKey="Pestova, Tv" uniqKey="Pestova T">TV Pestova</name></author><author><name sortKey="Hellen, Cu" uniqKey="Hellen C">CU Hellen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kolupaeva, Vg" uniqKey="Kolupaeva V">VG Kolupaeva</name></author><author><name sortKey="Lomakin, Ib" uniqKey="Lomakin I">IB Lomakin</name></author><author><name sortKey="Pestova, Tv" uniqKey="Pestova T">TV Pestova</name></author><author><name sortKey="Hellen, Cu" uniqKey="Hellen C">CU Hellen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pestova, Tv" uniqKey="Pestova T">TV Pestova</name></author><author><name sortKey="Hellen, Cu" uniqKey="Hellen C">CU Hellen</name></author><author><name sortKey="Shatsky, In" uniqKey="Shatsky I">IN Shatsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, At" uniqKey="Clark A">AT Clark</name></author><author><name sortKey="Robertson, Me" uniqKey="Robertson M">ME Robertson</name></author><author><name sortKey="Conn, Gl" uniqKey="Conn G">GL Conn</name></author><author><name sortKey="Belsham, Gj" uniqKey="Belsham G">GJ Belsham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hellen, Cu" uniqKey="Hellen C">CU Hellen</name></author><author><name sortKey="Pestova, Tv" uniqKey="Pestova T">TV Pestova</name></author><author><name sortKey="Wimmer, E" uniqKey="Wimmer E">E Wimmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuge, S" uniqKey="Kuge S">S Kuge</name></author><author><name sortKey="Kawamura, N" uniqKey="Kawamura N">N Kawamura</name></author><author><name sortKey="Nomoto, A" uniqKey="Nomoto A">A Nomoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaminski, A" uniqKey="Kaminski A">A Kaminski</name></author><author><name sortKey="Poyry, Ta" uniqKey="Poyry T">TA Poyry</name></author><author><name sortKey="Skene, Pj" uniqKey="Skene P">PJ Skene</name></author><author><name sortKey="Jackson, Rj" uniqKey="Jackson R">RJ Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kozak, M" uniqKey="Kozak M">M Kozak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andreev, De" uniqKey="Andreev D">DE Andreev</name></author><author><name sortKey="Dmitriev, Se" uniqKey="Dmitriev S">SE Dmitriev</name></author><author><name sortKey="Terenin, Im" uniqKey="Terenin I">IM Terenin</name></author><author><name sortKey="Prassolov, Vs" uniqKey="Prassolov V">VS Prassolov</name></author><author><name sortKey="Merrick, Wc" uniqKey="Merrick W">WC Merrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dmitriev, Se" uniqKey="Dmitriev S">SE Dmitriev</name></author><author><name sortKey="Pisarev, Av" uniqKey="Pisarev A">AV Pisarev</name></author><author><name sortKey="Rubtsova, Mp" uniqKey="Rubtsova M">MP Rubtsova</name></author><author><name sortKey="Dunaevsky, Ye" uniqKey="Dunaevsky Y">YE Dunaevsky</name></author><author><name sortKey="Shatsky, In" uniqKey="Shatsky I">IN Shatsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kozak, M" uniqKey="Kozak M">M Kozak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anthony, Dd" uniqKey="Anthony D">DD Anthony</name></author><author><name sortKey="Merrick, Wc" uniqKey="Merrick W">WC Merrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colon Ramos, Da" uniqKey="Colon Ramos D">DA Colon-Ramos</name></author><author><name sortKey="Shenvi, Cl" uniqKey="Shenvi C">CL Shenvi</name></author><author><name sortKey="Weitzel, Dh" uniqKey="Weitzel D">DH Weitzel</name></author><author><name sortKey="Gan, Ec" uniqKey="Gan E">EC Gan</name></author><author><name sortKey="Matts, R" uniqKey="Matts R">R Matts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuker, M" uniqKey="Zuker M">M Zuker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Ivanov, Ka" uniqKey="Ivanov K">KA Ivanov</name></author><author><name sortKey="Putics, A" uniqKey="Putics A">A Putics</name></author><author><name sortKey="Hertzig, T" uniqKey="Hertzig T">T Hertzig</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B Schelle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, Mm" uniqKey="Lai M">MM Lai</name></author><author><name sortKey="Brayton, Pr" uniqKey="Brayton P">PR Brayton</name></author><author><name sortKey="Armen, Rc" uniqKey="Armen R">RC Armen</name></author><author><name sortKey="Patton, Cd" uniqKey="Patton C">CD Patton</name></author><author><name sortKey="Pugh, C" uniqKey="Pugh C">C Pugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Sc" uniqKey="Chen S">SC Chen</name></author><author><name sortKey="Olsthoorn, Rc" uniqKey="Olsthoorn R">RC Olsthoorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almeida, Ms" uniqKey="Almeida M">MS Almeida</name></author><author><name sortKey="Johnson, Ma" uniqKey="Johnson M">MA Johnson</name></author><author><name sortKey="Herrmann, T" uniqKey="Herrmann T">T Herrmann</name></author><author><name sortKey="Geralt, M" uniqKey="Geralt M">M Geralt</name></author><author><name sortKey="Wuthrich, K" uniqKey="Wuthrich K">K Wuthrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eberle, Ab" uniqKey="Eberle A">AB Eberle</name></author><author><name sortKey="Lykke Andersen, S" uniqKey="Lykke Andersen S">S Lykke-Andersen</name></author><author><name sortKey="Muhlemann, O" uniqKey="Muhlemann O">O Muhlemann</name></author><author><name sortKey="Jensen, Th" uniqKey="Jensen T">TH Jensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doma, Mk" uniqKey="Doma M">MK Doma</name></author><author><name sortKey="Parker, R" uniqKey="Parker R">R Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graille, M" uniqKey="Graille M">M Graille</name></author><author><name sortKey="Chaillet, M" uniqKey="Chaillet M">M Chaillet</name></author><author><name sortKey="Van Tilbeurgh, H" uniqKey="Van Tilbeurgh H">H van Tilbeurgh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Hh" uniqKey="Lee H">HH Lee</name></author><author><name sortKey="Kim, Ys" uniqKey="Kim Y">YS Kim</name></author><author><name sortKey="Kim, Kh" uniqKey="Kim K">KH Kim</name></author><author><name sortKey="Heo, I" uniqKey="Heo I">I Heo</name></author><author><name sortKey="Kim, Sk" uniqKey="Kim S">SK Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Hoof, A" uniqKey="Van Hoof A">A van Hoof</name></author><author><name sortKey="Frischmeyer, Pa" uniqKey="Frischmeyer P">PA Frischmeyer</name></author><author><name sortKey="Dietz, Hc" uniqKey="Dietz H">HC Dietz</name></author><author><name sortKey="Parker, R" uniqKey="Parker R">R Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaeffer, D" uniqKey="Schaeffer D">D Schaeffer</name></author><author><name sortKey="Tsanova, B" uniqKey="Tsanova B">B Tsanova</name></author><author><name sortKey="Barbas, A" uniqKey="Barbas A">A Barbas</name></author><author><name sortKey="Reis, Fp" uniqKey="Reis F">FP Reis</name></author><author><name sortKey="Dastidar, Eg" uniqKey="Dastidar E">EG Dastidar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lebreton, A" uniqKey="Lebreton A">A Lebreton</name></author><author><name sortKey="Tomecki, R" uniqKey="Tomecki R">R Tomecki</name></author><author><name sortKey="Dziembowski, A" uniqKey="Dziembowski A">A Dziembowski</name></author><author><name sortKey="Seraphin, B" uniqKey="Seraphin B">B Seraphin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaeffer, D" uniqKey="Schaeffer D">D Schaeffer</name></author><author><name sortKey="Van Hoof, A" uniqKey="Van Hoof A">A van Hoof</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolin, Sl" uniqKey="Wolin S">SL Wolin</name></author><author><name sortKey="Walter, P" uniqKey="Walter P">P Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ingolia, Nt" uniqKey="Ingolia N">NT Ingolia</name></author><author><name sortKey="Ghaemmaghami, S" uniqKey="Ghaemmaghami S">S Ghaemmaghami</name></author><author><name sortKey="Newman, Jr" uniqKey="Newman J">JR Newman</name></author><author><name sortKey="Weissman, Js" uniqKey="Weissman J">JS Weissman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cencic, R" uniqKey="Cencic R">R Cencic</name></author><author><name sortKey="Desforges, M" uniqKey="Desforges M">M Desforges</name></author><author><name sortKey="Hall, Dr" uniqKey="Hall D">DR Hall</name></author><author><name sortKey="Kozakov, D" uniqKey="Kozakov D">D Kozakov</name></author><author><name sortKey="Du, Y" uniqKey="Du Y">Y Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honda, M" uniqKey="Honda M">M Honda</name></author><author><name sortKey="Kaneko, S" uniqKey="Kaneko S">S Kaneko</name></author><author><name sortKey="Matsushita, E" uniqKey="Matsushita E">E Matsushita</name></author><author><name sortKey="Kobayashi, K" uniqKey="Kobayashi K">K Kobayashi</name></author><author><name sortKey="Abell, Ga" uniqKey="Abell G">GA Abell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouvet, M" uniqKey="Bouvet M">M Bouvet</name></author><author><name sortKey="Debarnot, C" uniqKey="Debarnot C">C Debarnot</name></author><author><name sortKey="Imbert, I" uniqKey="Imbert I">I Imbert</name></author><author><name sortKey="Selisko, B" uniqKey="Selisko B">B Selisko</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Cai, H" uniqKey="Cai H">H Cai</name></author><author><name sortKey="Pan, J" uniqKey="Pan J">J Pan</name></author><author><name sortKey="Xiang, N" uniqKey="Xiang N">N Xiang</name></author><author><name sortKey="Tien, P" uniqKey="Tien P">P Tien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Tm" uniqKey="Coleman T">TM Coleman</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Huang, F" uniqKey="Huang F">F Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ypma Wong, Mf" uniqKey="Ypma Wong M">MF Ypma-Wong</name></author><author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harcourt, Bh" uniqKey="Harcourt B">BH Harcourt</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D Jukneliene</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A Kanjanahaluethai</name></author><author><name sortKey="Bechill, J" uniqKey="Bechill J">J Bechill</name></author><author><name sortKey="Severson, Km" uniqKey="Severson K">KM Severson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P Wadhwani</name></author><author><name sortKey="Mesters, Jr" uniqKey="Mesters J">JR Mesters</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egloff, Mp" uniqKey="Egloff M">MP Egloff</name></author><author><name sortKey="Ferron, F" uniqKey="Ferron F">F Ferron</name></author><author><name sortKey="Campanacci, V" uniqKey="Campanacci V">V Campanacci</name></author><author><name sortKey="Longhi, S" uniqKey="Longhi S">S Longhi</name></author><author><name sortKey="Rancurel, C" uniqKey="Rancurel C">C Rancurel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blyn, Lb" uniqKey="Blyn L">LB Blyn</name></author><author><name sortKey="Swiderek, Km" uniqKey="Swiderek K">KM Swiderek</name></author><author><name sortKey="Richards, O" uniqKey="Richards O">O Richards</name></author><author><name sortKey="Stahl, Dc" uniqKey="Stahl D">DC Stahl</name></author><author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Huang, Cheng" sort="Huang, Cheng" uniqKey="Huang C" first="Cheng" last="Huang">Cheng Huang</name></region><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G." last="Lokugamage">Kumari G. Lokugamage</name><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><name sortKey="Narayanan, Krishna" sort="Narayanan, Krishna" uniqKey="Narayanan K" first="Krishna" last="Narayanan">Krishna Narayanan</name><name sortKey="Rozovics, Janet M" sort="Rozovics, Janet M" uniqKey="Rozovics J" first="Janet M." last="Rozovics">Janet M. Rozovics</name><name sortKey="Semler, Bert L" sort="Semler, Bert L" uniqKey="Semler B" first="Bert L." last="Semler">Bert L. Semler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002053 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002053 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3234236
|texte= SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22174690" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |